Production of an enterotoxin different from toxin A byClostridium difficile
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چکیده
منابع مشابه
Clostridium difficile enterotoxin (toxin A): new results.
JOHN STEPHEN,* SUSAN C. REDMOND,* TIMOTHY J. MITCHELL,* JULIAN KETLEY,* DAVID C. A. CANDY,? DOUGLAS W. BURDONt and RICHARD DANIEL§ *Department of Microbiology. University of Birmingham, P.O. Box 363, Birmingham B15 ZTT, U.K., tlnstitute of Child Health, Francis Road, Edgbaston, Birmingham B16 8ET. U.K. , $Department of Microbiology, General Hospital, Steelhouse Lane, Birmingham B4 6NH U.K. , an...
متن کاملToxin A (enterotoxin) from Clostridium difficile in antibiotic-associated colitis.
severe, interstitial pneumonitis of undetermined cause. The remaining animals were anaesthetised, systemically perfused with buffered solutions of paraformaldehyde followed by glutaraldehyde, and tissue prepared for examination in 1 m epoxy cross-sections stained with toluidine-blue. Examination of cortex, cerebellum, spinal cord, sciatic-nerve complex, and gastrocnemius muscle revealed no toxi...
متن کاملEFFECT OF AMYGDALUS COMMUNIS ON GROWTH AND TOXIN PRODUCTION OF CLOSTRIDIUM DIFFICILE
It is known that the major etiologic agent of pseudomembranous colitis in man is Clostridium difficile. With respect to traditional use of almond paste in the treatment of infantile diarrhea, we studied the effects of the aqueous extract of Amygdalus communis (AEAC) on the growth and toxin production of Clostridium difficile in culture medium and the rabbit ligated ileal loop. Three groups...
متن کاملPRODUCTION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES TO CLOSTRIDIUM PERFRINGENS ENTEROTOXIN DERIVED FROM DIFFERENT ANIMAL SPECIES
The enterotoxins (ETs) of Clostridium perfringens isolated from enterotoxemic or diarrheic alpacas, pigs, calves, dogs, and horses were obtained from sporulated cell extracts. The ETs from alpaca, pig, and calf isolates were chromatographed on Sephadex G-lOO. Monoclonal antibodies (MAbs) against ETs derived from alpaca, pig, and calf C. perfringens isolates were produced. The MAbs were used...
متن کاملFidaxomicin inhibits toxin production in Clostridium difficile.
OBJECTIVES Fidaxomicin, which was recently approved for the treatment of Clostridium difficile-associated diarrhoea, demonstrates narrow-spectrum bactericidal activity via inhibition of RNA polymerase. In this study we evaluated its inhibitory activity versus C. difficile toxin gene expression and toxin production by quantifying toxin mRNA and protein. METHODS The effects of fidaxomicin, its ...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1988
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.1988.tb02936.x